Course and Module Catalogue

The module is designed to be an extension of MCB1, where cells and tissues are studied in more depth. The nature of biological membranes is considered in detail, particularly the more complex phospholipids and glycolipids. The module extends to consider how cells exist in tissues and the role of extracellular matrix components and cell junctions in cellular interactions is considered. Material covered in a number of earlier modules is integrated in order to appreciate the complexity of multicellular organisms and the problems associated with communication between cells. Two second messenger systems (cyclic 3'-5' adenosine monophosphate and inositol phospholipids) are covered in depth in order to focus on the problems associated with transduction of signals across biological membranes. Cellular communication is covered, including signalling membrane receptors and intracellular signalling pathways. Different types of cell communication are highlighted using specific tissue/cell type examples. The practical element of the module involves the sub-cellular fractionation of tissue derived cells and the identification of the appropriate marker enzymes in the separate sub-cellular fractions.