Precision Medicine - SMP4008

Assessment 1: Quizzes / polls

Feedback will be provided on a formative basis through quizzes, Q&amp;A sessions and tutorials practical reports covering all aspects of the module (a-g).

Quizzes/polls

Assessment 4: Exam

Exam

Assessment 3: In-Class Test

In-Class Test

Assessment 1: Written Assignment

Pharmacogenomics Flyer/Scientific poster
Max 500 words

Written Assignment

Assessment 2: Written Assignment

Drug Design and Development

SMP0002 - Drug Design and Development

An introduction to precision medicine including pharmacogenomics, which will be extended to an in-depth appreciation on how genetic variations are inherited and can be applied to pharmacogenomic analysis, i.e. how genetic variations affect human drug response and how this area is important to pharmacists, in particular looking to where future and current systems for medicines prescribing incorporate pharmacogenomics data. The pharmacogenomics of individual drugs will be explored using both virtual case studies and active systems including those currently integrated into the NHS, where multidisciplinary teams/stakeholders are involved. The module will also explore the application of biomarkers, including pharmacogenomic biomarkers, to stratified or personalised medicine. Both pharmacodynamics and pharmacokinetics influences of drugs will be covered, such as inter-patient variation in the expression of drug metabolising and activating enzymes; as well as differences in the expression of drug targets such as receptors, enzymes and transporters. Bioinformatics will be explored through the understanding of the development of the Human Genome Project (HGP) and its relevance to ‘OMIC’ technologies (genomics, proteomics, and transcriptomics) and Next Generation Sequencing technologies. In addition, different model systems that are used to identify and develop biomarkers and drug target identification will be covered.

School of Applied Sciences

Concepts in pharmacogenomics. Authors: Zdanowicz, Martin M. Type: Book ISBN: 9781585285174. Publisher: American Society of Health-System Pharmacists
Principles of pharmacogenomics and pharmacogenomics. Author: Altman, R; Flockhart and D A; Goldstein, D B. Type: Book ISBN: 052188537x. Publisher: Cambridge University Press
Biomarkers: in medicine, drug discovery, and environmental health. Authors: Vaidya, V S and Bonventre, J.V. Type: Book. ISBN: 0470452242. Publisher: Wiley Oxford
Oxford Dictionary of Biochemistry and Molecular Biology. Authors: Atwood, T; Campbell, P; Parish, H; Smith, A; Vella, F; Stirling, J and Cammack, R. Type: Book. ISBN: 0198529171. Publisher: OUP Oxford
Molecular biology of the cell. Authors: Bruce, A. Type: Book. ISBN: 9780815344643. Publisher: Garland Science Taylor and Francis Group

<a href="https://library.hud.ac.uk/readinglists/SMP4008">https://library.hud.ac.uk/readinglists/SMP4008</a>

Pharmacy

SMP4008 - Precision Medicine

Precision Medicine

Evaluate how genetic variation can impact patient drug interactions through pharmacodynamic and pharmacokinetic processes.

Apply pharmacokinetic principles to dosage adjustment of medicines in patients.

Examine how, pharmacogenomic data can impact medicines prescribing/dosing. 

Demonstrate a critical awareness of the impact of genomic/genetic studies on understanding drug response and adverse drug reactions.  

Understand how advanced techniques and bioinformatics are used in drug design and biomarker development.

Demonstrate a critical awareness and in-depth appreciation of precision medicine including genomic medicine and pharmacogenomics.