Please note

This document only provides information for the academic year selected and does not form part of the student contract

School:

School of Applied Sciences

Credit Rating:

20

Level (including FHEQ):

H (FHEQ Level 6)

Graded or Non Graded:

Graded

Version Valid From:

2022-09-01

Module Leader:

Duncan Gill

Version Number

2023.02

Learning Methods

Guided Independent Study
Seminar
Lecture

Requirements

Recommended Prior Study

Professional Body Requirements

Royal Society of Chemistry

Synopsis

This module will cover the molecular and cellular targets of medicines and will focus on the biological macromolecules that they interact with. Key classes of biological macromolecules will be covered including: proteins (enzymes and receptors) and nucleic acids (DNA, RNA and their biosynthetic machinery). The main focus of the lectures … For more content click the Read More button below.

Learning Strategy

A variety of activities will be used to provide the desired learning experience.  Knowledge transfer will be achieved via lectures and directed private study.  Tutorials will be used to allow students to integrate their learning by problem solving exercises.

Outline Syllabus

Molecular and cellular targets for medicines, their location, properties, functions;Drug – target intermolecular interactions;Proteins structure and function;Enzyme structure and catalysis, coenzymes, mechanisms of enzyme action;Receptor structure and function;Enzymes as drug targets: reversible and irreversible inhibitors; orthosteric and allosteric inhibitors; transition state inhibitors and mechanism-based (suicide) inhibitors;Receptors as drug targets: agonists, … For more content click the Read More button below.

Learning Outcomes

On successful completion of this module students will
1.
know the chemical and biochemical principles that provide an understanding of drug action.
2.
know the structure and function of biological macromolecules as both targets for medicines and as for their use as medicines themselves.
3.
know how structure activity relationships and lead optimization are used in drug design.
4.
be able to identify targets for therapeutic treatments.
5.
be able to design and develop protocols for the optimization of lead compounds to provide active ingredients.

Formative Assessment

Assessment 1: Quizzes / polls
Assessment 2: Other

Summative Assessment

Assessment 1: In-Class Test
Assessment 2: Exam

Assessment Criteria

In addition to the standard assessment criteria appropriate to a module of this level, additional credit will be given to students who demonstrate an ability to apply the knowledge and skills included in the module to debate, problem solve and make decisions in relation to the design of medicines.  The … For more content click the Read More button below.

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