Drug Synthesis Metabolism and Analysis

Please note

This document only provides information for the academic year selected and does not form part of the student contract

School:

School of Applied Sciences

Credit Rating:

Level (including FHEQ):

I (FHEQ Level 5)

Graded or Non Graded:

Graded

Version Valid From:

2018-09-01

Module Leader:

Duncan Gill

Version Number

2022.01

Learning Methods

Practical Classes and Demonstrations

Tutorial and Project Supervision

Guided Independent Study

Lecture

Synopsis

This module will provide a thorough understanding of the reactions that are used to construct and metabolise drugs including Phase 1 and 2 metabolic pathways for the elimination of drugs from the body. The synthetic aspects of organic chemistry covered in this module will develop an understanding of design, development … For more content click the Read More button below. Building on SFP1004, more advanced aspects of stereochemistry will be covered, and the relationship between shape, reactivity, biological and pharmacological action explored. The module will include a significant practical component which will focus upon the use of more advanced techniques for the preparation, analysis and isolation of drug molecules. Students will present a poster.

The synthetic aspects of organic chemistry covered in this module will develop an understanding of design, development and manufacture of pharmaceuticals.

Building on SFP1004, more advanced aspects of stereochemistry will be covered, and the relationship between shape, reactivity, biological and pharmacological action explored.

The module will include a significant practical component which will focus upon the use of more advanced techniques for the preparation, analysis and isolation of drug molecules.

Students will present a poster.

Learning Strategy

Lectures will be used to deliver the majority of the material. Tutorials will be used to develop the problem solving ability of the students and these are patient-related. Practical classes will reinforce the synthetic chemistry and analytical chemistry aspects of the lecture material. Part of the students’ directed time involves … For more content click the Read More button below.

Lectures will be used to deliver the majority of the material. Tutorials will be used to develop the problem solving ability of the students and these are patient-related.

Practical classes will reinforce the synthetic chemistry and analytical chemistry aspects of the lecture material.

Part of the students’ directed time involves the collation of results for each practical exercise and the presentation of these in the form of write-ups with interpretations and conclusions. The rest of their directed study time will involve the completion of tasks related to tutorial questions which encompass both factual and problem-solving type questions.

Outline Syllabus

Synthesis in action: the use of the major classes of reactions in the chemical synthesis of substances used in medicine, and the role of these reactions in biologically active molecules found in living systemsThe occurrence, properties (physical and chemical), synthesis and relevance of amino acids, peptides and carbohydratesThe occurrence, properties … For more content click the Read More button below.

Synthesis in action: the use of the major classes of reactions in the chemical synthesis of substances used in medicine, and the role of these reactions in biologically active molecules found in living systems
The occurrence, properties (physical and chemical), synthesis and relevance of amino acids, peptides and carbohydrates
The occurrence, properties (physical and chemical), synthesis and relevance of important heterocyclic compounds found in medicines (including simple heterocyclic rings such as pyridines, pyrroles, furans as well as imidazoles, benzothiazepines, the DNA bases, benzodiazepines and β-lactams). All classes will be illustrated with examples or synthetic case studies of the discovery and design of drugs in current use
Metabolism in action: Phase I and Phase II metabolic routes and the pharmacokinetics with respect to the renal excretion of drugs
Pro-drugs: The impact of drug metabolism upon drug design
Chemical kinetics and relevant thermodynamics
The isolation, purification and identification of substances used in medicines including physical and chemical tests, chromatographic techniques, extraction techniques, isolation procedures and separation science (see SFP1004)
The principles, design and development of analytical methods for organic molecules and their validation and application in practical settings (see SIP2005)
Poster presentation skills

Learning Outcomes

On successful completion of this module students will

be able to discuss the critical role of chemical synthesis and metabolic processes and appreciate the central role played by organic chemical reactions in the synthesis, analysis, metabolism (including kinetics), chemical reactivity and biological activity of drug molecules.

be able to describe reactions that enable the construction of amino acids, heterocycles and other molecules of biological and pharmaceutical interest.

be able to describe the methods used for the isolation, purification, identification and analysis of such substances.

be able to 4) Illustrate the major classes of reaction used in the construction of new bonds and use these reactions to understand metabolic routes and to appreciate the design of substances used in medicine of chemical synthetic origin.

be able to demonstrate an understanding of the chemical synthesis, phase I and phase II metabolic routes, and analytical methods for a number of top selling pharmaceutical substances and appreciate the fundamental role of organic chemistry in these processes.

be able to safely undertake organic synthetic procedures and analytical methods in a laboratory environment.

Formative Assessment

Assessment 1: In-Class Test

Assessment Criteria

The module handbook will provide additional guidance for students on the specific assessment criteria and marking schedules applied to individual pieces of work.

Course and Module Catalogue